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A highly-driven, aspiring neuroscientist, exploring the scientific mysteries of the microbiota-gut-brain axis and elucidating its role in central and peripheral nervous systems disorders.
Microbes have harmoniously co-evolved with their host and developed a symbiotic bond that is essential in normal neurodevelopment, immune maturation and confers protection against foreign pathogens. They have been identified to modulate activity in the brain via various modalities of communication, and are found to be distinctly altered in individuals with neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
As there is no cure, developing innovative strategies to curtail the disease progression is necessary. As a doctoral student in Dr. Anumantha Kanthasamy's Lab at the Center of Brain Sciences and Neurodegenerative diseases (CBSND), University of Georgia (UGA), my research entails conducting R&D for novel microbiome-based therapeutics to deliver L-DOPA in a continuous, non-pulsatile manner in pre-clinical animal models of PD and AD. As a new mode of delivery, our goal is to curtail the progression of Parkinson's and Alzheimer's disease and deliver clinical outcomes that will one day, benefit patients and society.
News & Events
Publications & Pre-prints
Patents
MICROENCAPSULATED AND CHROMOSOME INTEGRATED COMPOSITIONS FOR L-DOPA MICROBIOME THERAPY. https://uspto.report/patent/app/2022003177
MICROENCAPSULATED AND CHROMOSOME INTEGRATED COMPOSITIONS FOR L-DOPA MICROBIOME THERAPY. https://uspto.report/patent/app/2022003177
Invited Talks & Oral Presentations
Invited Talks & Oral Presentations
Division for Translational and Clinical Pharmacology - Young Investigator Awards Platform and Early Career Faculty Showcase : "Emerging Microbiome Genetic Engineering Technology for Stable Levodopa Delivery in Parkinson’s Disease” - ASPET at Experimental Biology, 2022.
Trainee Award Winner Presentation - SfRBM – Neurodegeneration and Aging Thematic Symposium: “Emerging Microbiome Genetic Engineering Technology for Stable Levodopa Delivery in Parkinson’s Disease”. SfRBM Annual Conference, 2021
Biomedical Science Seminar Series: “Engineered Live-Biotherapeutic Escherichia coli Nissle 1917 for Parkinson’s Disease” – Department of Biomedical Sciences, Iowa State University, 2021 (Invited)
Skills & Trainings
Skills & Trainings
Analytical Techniques
High-Performance Liquid Chromatography
Electrochemical Detection
Liquid Chromatography-Mass Spectrometry - Targeted and Quantitative Metabolite Detection
Microbiology
Bacterial Cell Culture
Transformation and Restriction Digest
Gel Electrophoresis
Bioreactor Fermentation
Molecular Biology
Western Blotting
PCR (RT, qPCR, RT-qPCR)
Immunohistochemistry
Cell Culture
Animal Handling and Monitoring
Animal Behavior
Locomotor and Neuromuscular function Tests (Open Field, Gait, Pole, Rotarod, Grip Strength)
Dyskinesia Tests (Cylinder with AIMS scoring)
Depressive-like Tests (Forced Swim, Tail Suspension, Sucrose Preference)
Cognitive Tests (Morris Water Maze, Cued and Contextual Fear Conditioning, Y-maze)
Anxiety Tests (Elevated Plus, Open-Field)
Startle Test (pre-pulse inhibition)
Gut Functional Assays
Animal Surgery
Stereotaxic Surgery
Animal Necropsy and Tissue processing
Organ, Gut, Lymph Node Dissections
Brain microdissections
Perfusion and Fixation
Interests & Passions
Interests & Passions
HipHop/Bollywood Dancing:
Sports:
Martial Arts and Kickboxing: Brazilian Jiujitsu, Muay Thai, Jiujitsu, Krav Maga
Black Belt and Kickboxing Instructor for 10 years
Soccer and Basketball
"You cannot teach a man anything; you can only help him discover it in himself "
"You cannot teach a man anything; you can only help him discover it in himself "
Galileo Galilei
Galileo Galilei
Feel free to connect with me through email or social media links!
Feel free to connect with me through email or social media links!
Email: piyushpadhi@uga.edu
Email: piyushpadhi@uga.edu
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